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Generation and repair of AID-initiated DNA lesions in B lymphocytes
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《医学前沿(英文)》 2014年 第8卷 第2期 页码 201-216 doi: 10.1007/s11684-014-0324-4
Activation-induced deaminase (AID) initiates the secondary antibody diversification process in B lymphocytes. In mammalian B cells, this process includes somatic hypermutation (SHM) and class switch recombination (CSR), both of which require AID. AID induces U:G mismatch lesions in DNA that are subsequently converted into point mutations or DNA double stranded breaks during SHM/CSR. In a physiological context, AID targets immunoglobulin (Ig) loci to mediate SHM/CSR. However, recent studies reveal genome-wide access of AID to numerous non-Ig loci. Thus, AID poses a threat to the genome of B cells if AID-initiated DNA lesions cannot be properly repaired. In this review, we focus on the molecular mechanisms that regulate the specificity of AID targeting and the repair pathways responsible for processing AID-initiated DNA lesions.
关键词: class switch recombination somatic hypermutation activation-induced deaminase DNA repair genomic instability
Expression and function of DMT1 without IRE in C6 cells mediated by recombinant adenovirus
Xixun DU*, Huamin XU*, Hong JIANG, Jun WANG, Lei WANG, Junxia XIE
《医学前沿(英文)》 2009年 第3卷 第1期 页码 67-71 doi: 10.1007/s11684-009-0010-0
关键词: divalent metal transporter 1 recombinant adenovirus homologous recombination iron
Detecting genetic hypermutability of gastrointestinal tumor by using a forensic STR kit
Anqi Chen, Suhua Zhang, Jixi Li, Chaoneng Ji, Jinzhong Chen, Chengtao Li
《医学前沿(英文)》 2020年 第14卷 第1期 页码 101-111 doi: 10.1007/s11684-019-0698-4
关键词: mismatch repair protein deficiency (MMR-D) microsatellite instability (MSI) short tandem repeats (STR) gastrointestinal tumor hypermutability
Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism:
null
《医学前沿(英文)》 2018年 第12卷 第3期 页码 319-323 doi: 10.1007/s11684-017-0553-4
Antithrombin and protein C are two crucial members in the anticoagulant system and play important roles in hemostasis. Mutations in and lead to deficiency or dysfunction of the two proteins, which could result in venous thromboembolism (VTE). Here, we report a Chinese 22-year-old young man who developed recurrent and serious VTE in cerebral veins, visceral veins, and deep veins of the lower extremity. Laboratory tests and direct sequencing of and were conducted for the patient and his family members. Coagulation tests revealed that the patient presented type I antithrombin deficiency combined with decreased protein C activity resulting from a small insertion mutation c.848_849insGATGT in and a short deletion variant c.572_574delAGA in . This combination of the two mutations was absent in 400 healthy subjects each from southern and northern China. Then, we summarized all the mutations of the and gene reported in the Chinese Han population. This study demonstrates that the combination of antithrombin deficiency and decreased protein C activity can result in severe VTE and that the coexistence of different genetic factors may increase the risk of VTE.
关键词: antithrombin deficiency protein C activity mutation variant venous thromboembolism anticoagulants
Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice
《医学前沿(英文)》 页码 957-971 doi: 10.1007/s11684-023-0988-8
关键词: DNAH10 mice motile cilia mutation primary ciliary dyskinesia
Leijing Liu, Hao Zhang, Bo Xiao, Yang Liu, Bin Xu, Chen Wang, Shanpeng Wen, Erjun Zhou, Gang Chen, Chan Im, Wenjing Tian
《化学科学与工程前沿(英文)》 2021年 第15卷 第1期 页码 127-137 doi: 10.1007/s11705-020-1936-7
关键词: third component organic solar cells charge carrier generation charge carrier recombination bimolecular recombination
Na Qin, Yuancheng Li, Cheng Wang, Meng Zhu, Juncheng Dai, Tongtong Hong, Demetrius Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Gary Goodman, Stig E. Bojesen, Maria Teresa Landi, Mattias Johansson, Angela Risch, H-Erich Wichmann, Heike Bickeboller, Gadi Rennert, Susanne Arnold, Paul Brennan, John K. Field, Sanjay Shete, Loic Le Marchand, Olle Melander, Hans Brunnstrom, Geoffrey Liu, Rayjean J. Hung, Angeline Andrew, Lambertus A. Kiemeney, Shan Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Penella Woll, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Victoria L. Stevens, Guangfu Jin, David C. Christiani, Zhibin Hu, Christopher I. Amos, Hongxia Ma, Hongbing Shen
《医学前沿(英文)》 2021年 第15卷 第2期 页码 275-291 doi: 10.1007/s11684-020-0779-4
关键词: lung cancer genome-wide association study function annotation immune homologous recombination repair deficiency genetic heterogeneity
Prevalence of vitamin D deficiency in girls with idiopathic central precocious puberty
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《医学前沿(英文)》 2018年 第12卷 第2期 页码 174-181 doi: 10.1007/s11684-017-0544-5
The relationship between vitamin D deficiency and idiopathic central precocious puberty (ICPP) has been recently documented. In this study, 280 girls diagnosed with ICPP and 188 normal puberty control girls of similar ages were enrolled and retrospectively studied. The ICPP group had significantly lower serum 25-hydroxyvitamin D (25[OH]D) levels than the control group. Furthermore, a nonlinear relationship was found between serum 25[OH]D and ICPP, and a cut-off point for serum 25[OH]D was found at 31.8 ng/ml for ICPP with and without adjusting the different confounding factors. Girls with serum 25[OH]D≥31.8 ng/ml had a lower odds ratio (unadjusted: OR 0.36, 95% CI 0.15 to 0.83, <0.05; height and weight adjusted: OR 0.44, 95% CI 0.18 to 1.08, = 0.072; BMI adjusted: OR 0.36, 95% CI 0.16 to 0.84, <0.05). The ICPP subjects with 25[OH]D deficiency had a higher body mass index (BMI) than the subjects from the two other subgroups. Correlation analysis showed that vitamin D level is correlated with BMI and some metabolic parameters in the ICPP group. Our study suggested that vitamin D status may be associated with ICPP risk and may have a threshold effect on ICPP.
关键词: idiopathic central precocious puberty threshold effects vitamin D status
Bile duct injury repair — earlier is not better
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《医学前沿(英文)》 2015年 第9卷 第4期 页码 508-511 doi: 10.1007/s11684-015-0418-7
Bile duct injury is a common complication of cholecystectomy. The timing of bile duct injury repair remains controversial. A recent review conducted in France reported 39% complications and 64% failure after immediate repair in 194 patients compared with 14% complications and 8% failure after late repair in 133 patients. A national review of 139 consecutive early repairs conducted at five hepatopancreaticobiliary centers in Denmark reported 4% mortality, 36% morbidity, and 42 restrictures (30%) at a median follow-up of 102 months, and only 64 patients (46%) demonstrated uneventful short-term and long-term outcomes. Most patients with bile duct injury present with bile leak and sepsis; thus, early repair is not recommended. Percutaneous drainage of bile and endoscopic stenting are the mainstays of treatment of bile leak because they convert acute bile duct injury into a controlled external biliary fistula. The ensuing benign biliary stricture should be repaired by a biliary surgeon after a delay of 4–6 weeks once the external biliary fistula has closed.
关键词: bile duct injury cholecystectomy laparoscopic cholecystectomy
《医学前沿(英文)》 doi: 10.1007/s11684-023-1001-2
关键词: iron deficiency anemia intravenous iron ferric carboxymaltose iron sucrose Hb response early response
Mobile platform for hydraulic turbine blade repair robot
GUI Zhongcheng, CHEN Qiang, SUN Zhenguo, ZHANG Wenzeng, LIU Kang
《机械工程前沿(英文)》 2008年 第3卷 第2期 页码 164-169 doi: 10.1007/s11465-008-0035-0
Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma
Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He
《医学前沿(英文)》 2019年 第13卷 第6期 页码 730-740 doi: 10.1007/s11684-019-0687-7
关键词: upper tract urothelial carcinoma GATA binding protein 3 mismatch repair microsatellite instability prognosis
Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota
Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,
《工程(英文)》 doi: 10.1016/j.eng.2023.06.007
关键词: Axin1 Bacteria Microbiome inflammation Inflammatory bowel disease Immunity Microbiome Paneth cells Akkermansia muciniphila Wnt
Yanhua GUAN, Ying GAO, Renjuan SUN, Moon C. WON, Zhi GE
《结构与土木工程前沿(英文)》 2017年 第11卷 第3期 页码 338-345 doi: 10.1007/s11709-017-0411-0
关键词: Calcium Sulfoaluminate (CSA) cement Type III cement coefficient of thermal expansion (CTE) shrinkage rapid repair
Xuran Chu, Chengshui Chen, Chaolei Chen, Jin-San Zhang, Saverio Bellusci, Xiaokun Li
《医学前沿(英文)》 2020年 第14卷 第3期 页码 262-272 doi: 10.1007/s11684-019-0717-5
标题 作者 时间 类型 操作
Expression and function of DMT1 without IRE in C6 cells mediated by recombinant adenovirus
Xixun DU*, Huamin XU*, Hong JIANG, Jun WANG, Lei WANG, Junxia XIE
期刊论文
Detecting genetic hypermutability of gastrointestinal tumor by using a forensic STR kit
Anqi Chen, Suhua Zhang, Jixi Li, Chaoneng Ji, Jinzhong Chen, Chengtao Li
期刊论文
Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism:
null
期刊论文
Effects of BTA2 as the third component on the charge carrier generation and recombination behavior of
Leijing Liu, Hao Zhang, Bo Xiao, Yang Liu, Bin Xu, Chen Wang, Shanpeng Wen, Erjun Zhou, Gang Chen, Chan Im, Wenjing Tian
期刊论文
Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma
Na Qin, Yuancheng Li, Cheng Wang, Meng Zhu, Juncheng Dai, Tongtong Hong, Demetrius Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Gary Goodman, Stig E. Bojesen, Maria Teresa Landi, Mattias Johansson, Angela Risch, H-Erich Wichmann, Heike Bickeboller, Gadi Rennert, Susanne Arnold, Paul Brennan, John K. Field, Sanjay Shete, Loic Le Marchand, Olle Melander, Hans Brunnstrom, Geoffrey Liu, Rayjean J. Hung, Angeline Andrew, Lambertus A. Kiemeney, Shan Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Penella Woll, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Victoria L. Stevens, Guangfu Jin, David C. Christiani, Zhibin Hu, Christopher I. Amos, Hongxia Ma, Hongbing Shen
期刊论文
non-inferiority trial of intravenous ferric carboxymaltose versus iron sucrose in patients with iron deficiency
期刊论文
Mobile platform for hydraulic turbine blade repair robot
GUI Zhongcheng, CHEN Qiang, SUN Zhenguo, ZHANG Wenzeng, LIU Kang
期刊论文
Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma
Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He
期刊论文
Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota
Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,
期刊论文
Experimental study and field application of calcium sulfoaluminate cement for rapid repair of concrete
Yanhua GUAN, Ying GAO, Renjuan SUN, Moon C. WON, Zhi GE
期刊论文